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點(diǎn)擊化學(xué)利用四嗪(Tetrazine)碳納米管實(shí)現(xiàn)預(yù)靶向腫瘤成像

西安瑞禧生物一家以客戶為中心的生物技術(shù)公司。我們致力于生產(chǎn)和供應(yīng)高純度聚乙二醇連接物，點(diǎn)擊化學(xué)工具和先進(jìn)的生物標(biāo)記試劑，如染料標(biāo)記和生物素標(biāo)記化合物，我們的客戶遍布世界各地。

利用TCO和Tz之間快速的正交切割反應(yīng)，把Tz搭載于腫瘤靶向性的納米材料單壁碳納米管SWCNTs上（Tz@SWCNTs），實(shí)現(xiàn)對(duì)腫瘤的預(yù)靶向激活。其主要原理：利用通透性增強(qiáng)與滯留效應(yīng)，使Tz@SWCNTs在腫瘤組織中積累。通過TCO前藥分子或探針，由在腫瘤處富集的Tz進(jìn)行正交切割。

通過研究tAMC與Tz@SWCNTs之間的釋放動(dòng)力學(xué)，相比于mTZ小分子，Tz@SWCNTs對(duì)tAMC的衰減反應(yīng)性更強(qiáng)，且能在生理環(huán)境下，對(duì)MCF-7癌細(xì)胞進(jìn)行靶向并激活tAMC熒光。

將陽離子染料半菁HCA和TCO相連得到近紅外熒光探針tHCA用于通過生物正交釋放反應(yīng)的激活近紅外熒光探針。該探針在生理環(huán)境下因Tz@SWCNTs的激發(fā)快速釋放，并在720nm下發(fā)出強(qiáng)熒光。

瑞禧相關(guān)產(chǎn)品：

Tetrazine-NHS Ester

Methyltetrazine-NHS Este

Tetrazine-Sulfo-NHS Ester

Methyltetrazine-Sulfo-NHS Ester

Tetrazine-PEG5-NHS Ester

Methyltetrazine-PEG4-NHS Ester

Methyltetrazine-PEG5-NHS Ester

Methyltetrazine-PEG4-Sulfo-NHS Ester

Methyltetrazine-Acid

Tetrazine-Acid

Methyltetrazine-PEG4-Acid

PC Methyltetrazine-NHS Ester

R-CT-013 Methyltetrazine-Amine

Tetrazine-Amine

Methyltetrazine-Propylamine

Methyltetrazine-PEG4-Amine

Methyltetrazine-PEG4-Maleimide

Bis-sulfone-PEG4-Tetrazine

ThioLinker-Tetrazine

Methyltetrazine-DBCO

Methyltetrazine-PEG12-DBCO

Methyltetrazine-PEG4-Alkyne

Methyltetrazine-PEG4-Azide

Methyltetrazine-mPEG,5 kDa

Methyltetrazine-mPEG, 10 kDa

Methyltetrazine-mPEG, 20 kDa

Methyltetrazine-mPEG, 30 kDa

Biotin-PEG4-Methyltetrazine

Cy3 Tetrazine

Cy3 Methyltetrazine

TAMRA Tetrazine

TAMRA Methyltetrazine

Cy7 Methyltetrazine

MethylTetrazine-amine HCl salt

Methyltetrazine-PEG4-COOH

MPEG-Tetrazine 

MethylTetrazine-amine HCl salt

Methyltetrazine-propylamine HCl salt

Methyltetrazine-PEG4-Alkyne  

Tetrazine-PEG4-amine HCl salt

Me-Tetrazine-PEG4-amine HCl salt

Tetrazine-PEG5-COOH

Tetrazine-PEG5-NHS ester